Technetium-labeled danofloxacin complex as a model for infection imaging

Technetium-99m tricarbonyl labeled a broad-spectrum quinolone as a specific imaging agent in infection diseases

Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in ...

Technetium-99m tricarbonyl labeled a broad-spectrum quinolone as a specific imaging agent in infection diseases

Nuclear medicine imaging has been used to localize infection sites and efforts have been continued to develop modified infection specific radiopharmaceuticals. In this study gemifloxacin as a broad-spectrum quinolone has been labeled with [99mTc (CO)3 (H2O)3]+ core in order to evaluate its feasibility as an infection imaging agent for in vivo use. The stability of radioconjugate was checked in ...

Technetium-99m-labeled chemotactic peptides: specific for imaging infection?

Technetium-99m-labeled annexin V imaging for detecting prosthetic joint infection in a rabbit model

Accurate and timely diagnosis of prosthetic joint infection is essential to initiate early treatment and achieve a favorable outcome. In this study, we used a rabbit model to assess the feasibility of technetium-99m-labeled annexin V for detecting prosthetic joint infection. Right knee arthroplasty was performed on 24 New Zealand rabbits. After surgery, methicillin-susceptible Staphylococcus au...

An improved synthesis and preliminary biodistribution study of a Technetium-99m-labeled 2-amino-2-deoxy(thioacetyl)-D-glucose complex ([99mTc]-TA-DG) as a tumor imaging agent

  Introduction: This report describes the synthesis of 2-Amino-2-deoxy(S-benzoylthioacetyl)-D-glucose (S-Bz-TA-DG), radiolabeled with [99mTc(CO)3(OH2)3]+ complex with a procedure including deprotection of the benzoyl group, characterization by HPLC using a C18 reverse phase column and preliminary biodistribution study in normal ...